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Disease search as:

Behcet, VKH, AAU, Fuchs, SO,

Pediatric uveitis, BSCR, Sarcoidosis,

Intermediate uveitis, PIC and MFC.

Welcome to UVEOGENE database

UVEOGENE is a new database which contains existing genes and SNPs which have been reported in different uveitis entities. Basic information (gene ID, RefSNP Alleles, Functional Consequences, Global MAF) of SNPs with reference to NCBI can be provided in the database. For each SNPs from publications, detail data (Method, related disease, Ethnicity, the number of Allele/Genotype in the cases and controls, PMID, etc) can also be performed so that data can be extracted for meta-analysis. UVEOGENE includes 370 genes and 918 SNPs covering 14 uveitis entities and 40 populations from 269 English-language papers.Stratification analyses by gender; HLA status and different clinical features were also extracted from publications. As a results, 371 associations were judged as 'significant' according to the statistical significant (All associations and significant associations can be downloaded in the 'downloads page'. Based on these associations, In the UVEOGENE established, we found that Behcet’s disease (BD) was the most common uveitic entity investigated, followed by Vogt Koyanagi Harada (VKH) disease and Acute Anterior Uveitis (AAU) . By using KEGG pathway analysis based on this database, 76, 46 and 51 pathways were found to be involved in BD, VKH disease and AAU, respectively. Additionally, users can access theses pathways in the pathway analysis pages in a graphical view whereby uveitis-related genes are mapped in red in the pathways. Three networks were also constructed for these three uveitis entities. In summary, 'UVEOGENE' provides a reliable, informative, comprehensive and well-organized resource in the study on genetic mechanisms involved in uveitis and can be used to identify similarities as well as differences in the genetic susceptibility to develop uveitis and other autoimmune or immune-driven diseases.